Avera joins a small group of institutions on the Plavix trail. Scripps Translational Science Institute of San Diego began similar research in 2009 and Vanderbilt in 2010.
the genetic code of individuals to treatments of certain ailments," David A. Pearce, vice president of research at Sanford, said Friday by email.
Patty Huizenga, a genetics research associate for Avera, plotted data from nine patients on her computer screen last week. Five of the nine turned up as blue dots in the upper left corner, indicating a liver that would effectively metabolize Plavix. Three more showed up as green dots near the center of the screen, indicating less promise. The ninth sample turned up red in the lower right, indicating poor performance.
"This will revise the way we do medicine, to look at DNA to determine how to control my pain," said Gareth Davies, scientific director for the Avera Institute for Human Genetics. "Wouldn't it be nice to know use this drug but don't use that one?"
Avera has collected 30 of the blood samples the first five weeks. Lab workers take each sample, extract the red blood cells and study the remaining white cells, which reveal a person's genetic data. While the code is massive for each individual, this work centers on a tiny sliver of data pertaining to the liver, the organ that metabolizes drugs.
'Let's just sequence everybody, then we'll know what to do.' There are some very specific applications where we think it can make a difference in clinical outcomes, but it's in a phase where it's not clearly proven," Eckman said.
Vanderbilt University Medical Center has collected DNA of 5,000 patients since it began screening for Plavix in 2010 and cholesterol lowering statins in 2011. The school also uses DNA samples from tumors to match chemotherapy to melanoma, lung, breast and colon cancer. John Howser, assistant vice chancellor, thinks drug companies are neutral to all of this. "If you test somebody and they're not metabolizing one drug, they're still going to need something," he said.
The University of Florida, like Avera, began this year, said Dr. Eric Topol, director at Scripps.
The work is for research only at this point, not to guide daily care. But officials think a day is coming when a doctor can order medication by reading a patient's genetic data off a cellphone.
"We can target specific pieces of the genome, a set of genes, and determine whether an individual is going to benefit or be at risk.".
"The problem is the human genome is immense. It's not something as simple as, Harden One Cargo
The project started in June at Avera's lab in southwest Sioux Falls. It centers on Plavix, a common prescription to prevent blood clots, but also a drug that doesn't work for Harden 1 Adidas Review
Dr. Peter Eckman, cardiologist at the University of Minnesota Medical Center, said the research on Plavix has great potential but that many institutions, such as his own, are not pursuing it.
"We are investigating the underlying contribution of Adidas Duramo Nova 2 Mens Review
Avera study tries to link DNA
"Still, I commend Avera for rolling this out, and am hopeful they will be able to contribute to our understanding on how to use this."
The medical industry is not in agreement, however. "There are other major academic centers that do not do this," Howser said from Nashville, Tenn. "Physicians at those centers are not yet convinced of the value. This is an emerging field. We were a very early adopter of it."
many who try it. Lab workers hope their work can clarify not only who's right for Plavix but can be a building block to extend personal medicine someday to other needs such as attention deficit, depression, cancer and pain relief.
Researchers at Avera Health have begun examining blood samples from coronary patients as a step toward using DNA to tailor prescriptions to individual needs.
Avera began June 20 to collect blood samples from patients who had undergone a coronary stent procedure at Avera Heart Hospital of South Dakota. A stent is a tiny tube the size of a piece of macaroni that doctors insert into an artery or vein to relieve pressure and improve blood flow. Stents prop open blood vessels, but they also can be collection points for debris, which makes those patients candidates for an anti clotting agent such as Plavix.
Other health networks, including Sanford in Sioux Falls, are on their own tracks in personalized care, though not necessarily with Plavix.
"This can eliminate a lot of the guessing game," Huizenga said.
"When is it ready for prime time? That's why we're doing this study," said Avera cardiologist Dr. Michael Hibbard.
Topol, director at Scripps, said 30 percent of patients have DNA that prevents metabolism Pharrell Adidas Nmd Human Race of Plavix. Those in that group who use the drug anyway also face a greater health risk. A study such as Avera's is timely, he said, because Plavix went generic in May. Someone who knows Plavix will work now can buy the cheaper generic, he said.
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